Subject(s)
Animals, Laboratory , Busulfan/toxicity , Mice , Testis/drug effects , Spermatozoa/drug effects , EpididymisABSTRACT
Investigamos prospectivamente a incidência de neuropatia periférica em 43 pacientes através do estudo da velocidade de conduçao nervosa e do teste de limiar de sensibilidade vibratória (palestesiômetro) realizados antes e após o transplante de medula óssea. Nesse período as principais drogas utilizadas para o condicionamento e imunossupressao foram o bussulfan, ciclofosfamida, ciclosporina A, methotrexate e corticoesteróides. Foram estudadas as velocidades de conduçao nervosa nos nervos mediano motor, fibular, tibial, mediano sensitivo e sural. Obtivemos alteraçoes estatisticamente significativas na duraçao do potencial composto proximal do nervo mediano motor, na amplitude distal do nervo tibial posterior e na amplitude proximal do nervo sural. As diferenças observadas nao se correlacionaram com alteraçoes clínicas, e nao foram suficientes para o diagnóstico de neuropatia periférica. Acreditamos que o esquema terapêutico utilizado nao provoca toxicidade neurológica periférica no período recente do transplante de medula óssea.
Subject(s)
Humans , Male , Female , Child , Adolescent , Adult , Middle Aged , Bone Marrow Transplantation , Peripheral Nervous System Diseases , Adrenal Cortex Hormones/toxicity , Busulfan/toxicity , Cross-Sectional Studies , Cyclophosphamide/toxicity , Cyclosporine/toxicity , Immunosuppressive Agents/toxicity , Incidence , Methotrexate/toxicity , Neural Conduction , Peripheral Nervous System Diseases/chemically induced , Postoperative Period , Prospective Studies , Risk Factors , Time FactorsABSTRACT
A case of cataract related to Busulfan [Myleran] was studied with light and electron microscopy. Clinical evaluation revealed bilateral posterior subcapsular cartaracts. Histological abnormalities included the presence of numerous abnormal dense bodies and Morgagnian globules in the anterior subcapsular region with marked cellular destruction and accumulation of granular debris posteriorly. Electron microscopy revealed that abnormal dense inclusions resembled myelinoid bodies. Acid phosphatase activity was localized in the epithelium and was hardly visible in the area of cellular necrosis. It is felt that the myleran - induced disturbance of polar lipid catabolism was responsible for cataract formation this case